The first human trial in Europe of a coronavirus vaccine has begun in Oxford

Re:The first human trial in Europe of a coronavirus vaccine ... by mattkrause on Thursday April 23, 2020 @08:11PM (#22963173)

This is exactly why you wouldn’t need a challenge trial: lots of people are already regularly exposed to the virus. Immunize some of them and see if the infection rate is lower in that group vs a control.

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Re:The first human trial in Europe of a coronavirus vaccine ... by claudeganon on Thursday April 23, 2020 @08:20PM (#22963238)

Except failed vaccines can induce a response that makes you more susceptible to the disease and with worse symptoms. It’s called antibody-dependent enhancement:

https://pubmed.ncbi.nlm.nih.gov/12725690/

Just about the last people you’d want to risk that kind of vaccine trial on are healthcare workers, who are already in short supply.

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Re:The first human trial in Europe of a coronavirus vaccine ... by mattkrause on Thursday April 23, 2020 @08:31PM (#22963314)

I didn’t say healthcare workers.

I said that there’s plenty of incidental exposure already: healthcare workers, yes, but also nearly everyone who’s leaving the home too. It is literally a pandemic!

This point is actually made in the article itself: they want to get it done while and where there’s community transmission to avoid the ethical fraught ness of a challenge trial.

For similar reasons, challenge trials also weren’t done for AIDS PrEP, since there were groups with enough lifestyle exposure to power a study.

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Re:The first human trial in Europe of a coronavirus vaccine ... by lbeltrame on Friday April 24, 2020 @01:58AM (#22965104)

Sinovac (which is testing an attenuated vaccine) published some data on a preprint[1] claiming it does not cause ADE.

[1] https://www.biorxiv.org/content/10.1101/2020.04.17.046375v1

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