Some examples that come to mind are pesticides/herbicides/synthetic fertilizers. The farming example is very on-point actually. Production agriculture has become synonomous with monocultures (growing one species) to maximize "yield", and it's having devastating consequences. We're killing micro organisms in the soil, which are necessary for nutrient exchange to the crops. Modern vegetables have 50-80% less nutrients than those of 50 years ago. The lack of diversity in plant species means a single predator/pest will not have any natural repellents, thus requiring pesticides. The soils, losing nutrients rapidly, now require additives in the form of synthetic fertilizers: nitrogen, prosperous, and potassium. We took a system that worked, tried to over engineer it, and created a whole mess of problems and additonal work/cost.

Another: We took cows, which have a special organ called a rumen that is specifically designed to extract nutrients from grasses, an abundant resource that many animals cannot use as a food source, and instead began feeding them diets of corn. The corn heavy diets is worse for the cows overall immune system, requiring the addition of antibiotics. Farmers who raise cows in balance with their natural state of a grass based diet will need little to no antibiotics.

Wood is making a massive comeback in the commercial construction industry because we realized it has some properties that we were too willing to dismiss, including it's flexibility and amazing strength-to-weight in relation to it's cost to produce.

I'm not anti-technology or anti-innovation, but I think it's also important to ask ourselves whether all this extra work we create for ourselves is actually necessary/beneficial. In the case of psilocybin synthesis/extracts, I'm a bit skeptical. I think we're trying to re-invent the wheel.