Amen. Legal in Canada so I've messed around with a few different types of edible solutions. The whole extract (i.e. using butter and then making brownies) hits way differently than isolated chemicals.

We'll need to figure out what those ingredients are, and how they work, and what negative effects they have.

Otherwise, we're being extremely unwise, and setting ourselves up for serious problems later.

Or you could just do longitudinal studies on the thousands of people who voluntarily consume these things without apparent ill effect. They don’t appear to be immediately toxic so any risk here is fairly long term. Lots of anecdata self-reporting on Erowid.