(Mu)Shrooms contain more more psychoactive substances and prodrugs to such than psilocybin. There is a reason why psychonauts debate differences between trips induced by Shrooms vs 4-Aco-DMT. But of course it would make sense to simplify the approach by starting with synthetic prodrugs.
Why are trials and research concentrating on this prodrug like it's necessary is beyond my understanding . It's a waste of money and time