I don't like screen readers, but I liked teaching applications to speak themselves based on text commands. I like to combine this with a braille reader and use both in different contexts. For example, a braille reader is more unambiguous with punctuation, capitalization, etc, but speech synthesis is necessary to catch my attention for a notification from a non-active application, and is more comfortable for reading natural language. It's worth reiterating, though, that I don't need these tools (yet), so people who depend on them daily may have a different opinion.

Braille is easy, I could read it reasonably well with just a couple of days of study.