There has been exciting work on directed evolution of enzymes for drug synthesis, particularly for transamination (conversion of a ketone to an amine). This is I believe being used commercially now, for example for the production of the diabetes drug sitagliptin.

https://blogs.sciencemag.org/pipeline/archives/2010/10/06/ch...

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002...