Re:Man dies after self-medicating with chloroquine
by HarryHirsch on Monday March 23, 2020 @07:55PM
(#22670249)
You got that wrong. Nitric oxide is a vasodilator, it relaxes smooth muscles in the blood vessels and lungs to increase blood and air flow. It has nothing to do with fighting coronavirus or any other kind of virus, it's supportive treatment so that the patient doesn't suffocate.
Re:Man dies after self-medicating with chloroquine
by Alex3917 on Monday March 23, 2020 @08:00PM
(#22670299)
> It has nothing to do with fighting coronavirus or any other kind of virus, it's supportive treatment so that the patient doesn't suffocate.
"Nitric Oxide Inhibits the Replication Cycle of Severe Acute Respiratory Syndrome Coronavirus"
https://jvi.asm.org/content/79/3/1966
...
Re:Man dies after self-medicating with chloroquine
by AstralStorm on Monday March 23, 2020 @11:42PM
(#22671652)
Nitric oxide ion in cell is not the same as nitrous oxide gas, typically used for sedation, not taking NO itself.
Enhancing NO signaling in cells is hard. The best initial bet there would be using certain class of beta-blockers. (Ones typically used for black patients.) But please do not take unproven drugs with known side effects.
The paper is talking about S-nitroso-N-acetylpenicillamine in vitro. This compound is not something anyone wants to actually take.
For any virus. I didn't say it was safe or effective, I said there is a plausible mechanism of action.