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A comment on About that Hydroxychloroquine for Covid-19 trial. Parent comment

Re:About that Hydroxychloroquine for Covid-19 trial by chasil on Monday March 23, 2020 @06:59AM (#22662796)
This drug has actually been mentioned in several past clinical studies on the closely-related SARS. The particular study below has been circulating in several areas online, and has citations to several more:

https://cmr.asm.org/content/20/4/660.long

Despite the role of the pH-sensitive endosomal protease cathepsin L in the entry pathway (151, 300), viral culture does not require pretreatment with trypsin. However, this pH-sensitive cathepsin L may be a target for agents such as chloroquine, which elevates endosomal pH (174, 341).

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Re:About that Hydroxychloroquine for Covid-19 trial by hanniabu on Monday March 23, 2020 @07:53AM (#22663110)
I'm sure I'm not the only one wondering this..... what does this mean in layman's terms?
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Re:About that Hydroxychloroquine for Covid-19 trial by treis on Monday March 23, 2020 @09:27AM (#22663894)
The chemical pathway that allows the virus to enter the cell changes based on the pH of the cell. Chloroquine changes the pH of that pathway and therefore may slow/stop the entry of the virus into the cell.
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