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Re:Chloroquine, past and present by zamalek on Saturday March 21, 2020 @12:19AM (#22644402)
> It may be useful in combo with other drugs

Weren't the first studies done in combination with azithromycin (which is bizzare, as that's an antibiotic)?

Re:Chloroquine, past and present by red-indian on Saturday March 21, 2020 @01:19AM (#22644674)
The azithromycin was given to some of the patients with viral pneumonia as there is a chance of reinfection with bacterial pneumonia. Astonishing and unexpectedly, the covid19 virus was completely wiped out in all the HCQ+azithromycin patients but only in a bit over half the HCQ alone patients. So just as an antiparasite drug surprisingly once was found to also work as an antiviral, azithromycin has unexpectedly been found to have some sort of a complementary amplifying or catalyzing effect with the hydrochloroquine. Of unknown mechanism and no doubt this will be explored in great detail in future research. For now it's known that putting the two together looks to be a good thing to do.
Re:Chloroquine, past and present by aaavl2821 on Saturday March 21, 2020 @03:30AM (#22645174)
It may be early to conclude that azithromycin has a complementary mechanism with HCQ, the study was too small and there are too many confounding factors. It is possible there is some synergy but also possible that there is not
Re:Chloroquine, past and present by paulmd on Saturday March 21, 2020 @02:01AM (#22644852)
the problem is quite simple: the virus infects your body, damages your lungs, and fucks up your immune system. Then you get an opportunistic pneumonia

The mechanism is also quite simple: administer them both together and the antimalarials kill the virus, the antibiotics kill the pneumonia.

Re:Chloroquine, past and present by romski on Saturday March 21, 2020 @03:32AM (#22645178)
you're not really an md, are you?
Re:Chloroquine, past and present by paulmd on Saturday March 21, 2020 @06:00AM (#22645578)
No. Now let's have a look at that bwain of yours.
Re:Chloroquine, past and present by gumby on Saturday March 21, 2020 @11:48PM (#22652573)
Azithromycin has been shown to have some antiviral effect though it has not been characterized and the mechanism of action is unknown.

I assume they chose that as a broad spectrum prophylaxis for and opportunistic concurrent infection but perhaps they chose it specifically for this reason.