I have a friend with Crohn's disease who read all of the research on hookworm, found a company that would ship it to Canada, went to Canada, and got himself infected. Several months later he has managed to discontinue most of the drugs and he is feeling better than he has in years.

Unfortunately hookworm has been classified as a medication in the USA, and is unpatentable, so will never be approved as a treatment here. But if you're willing to travel abroad, look into it. Seriously.