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Re:Chloroquine has shown apparent efficacy in treatment of C... by jimmyswimmy on Tuesday March 17, 2020 @12:27AM (#22601670)
So, I'm no medical professional, just an avid reader of such news. But I believe that most of this post is incorrect.

I've seen no studies backing up the use of zinc for anything related to COVID-19. A search of pubmed for the terms 'covid zinc' or 'coronavirus zinc' show no papers referencing treatments. Same goes for medrxiv.

There are a lot of cold "treatments" involving the use of zinc in the way you suggest. I have even seen studies which support its use as a prophylactic to the common cold (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273967/) though that one makes no reference to a common side effect, particularly the way you recommend its use, which is loss of sense of smell.

Further, I haven't read anywhere about the mechanism of infection you propose for this disease. It is said to attack the lungs, liver and small intestine due to its furin cleavage site (https://www.biorxiv.org/content/10.1101/2020.02.10.942185v1).

Finally, I am nearly certain you are spreading bad information about how this treatment works. Chloroquine is provided after active symptoms present. The first few days of infection are asymptomatic for most patients, certainly the first 4-7 days, if not longer. There is no medical call for treatment until a patient presents symptoms, and your advice risks leading people to attempt to hoard this medication.

We agree that chloroquine is indeed cheap.

Re:Chloroquine has shown apparent efficacy in treatment of C... by ComputerGuru on Tuesday March 17, 2020 @12:53AM (#22601799)
Not vouching for the suggested treatment but chloroquine acts as a zinc ionophere enabling increased zinc binding/intake in cells, inhibiting RNA-dependent RNA polymerase, which would theoretically ultimately encumber the replication of the virus.
Re:Chloroquine has shown apparent efficacy in treatment of C... by dboreham on Tuesday March 17, 2020 @01:20AM (#22601958)
Right. The Zinc is already present intercellular, unless the patient is Zinc deficient.
Re:Chloroquine has shown apparent efficacy in treatment of C... by ethbro on Monday March 16, 2020 @11:41PM (#22601407)
> allowing time to clear the virus from the body without raising an excessive immune response ("cytokine storm")

Citation requested, that cytokine storms are a common pathology associated with Covid-19.

Because (a) I haven't seen that in the literature, & (b) it's at odds with the published age-banded mortality rates.

Re:Chloroquine has shown apparent efficacy in treatment of C... by tlb on Monday March 16, 2020 @11:43PM (#22601422)
Re:Chloroquine has shown apparent efficacy in treatment of C... by IAmEveryone on Tuesday March 17, 2020 @01:09AM (#22601904)
For reasons beyond my understanding, the internet (or maybe just HN) has been in love with cytokines storms for a decade or so. Far more than warranted by the actual significance of the phenomenon relative to others.

It’s like quicksand in 19th century pop culture.

Re:Chloroquine has shown apparent efficacy in treatment of C... by drewmol on Tuesday March 17, 2020 @01:00AM (#22601846)
"We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients."

[0]https://academic.oup.com/cid/advance-article/doi/10.1093/cid...

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Re:Chloroquine has shown apparent efficacy in treatment of C... by nl on Monday March 16, 2020 @11:59PM (#22601511)
It's settled fact that the covid-19 pneumonia is a result of a "cytochine storm".

This just isn't true. It maybe true for a subset of patients in some circumstances. To quote your first link:

Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome.

Re:Chloroquine has shown apparent efficacy in treatment of C... by solotronics on Monday March 16, 2020 @11:31PM (#22601344)
where do I get chloroquine? is this something I can ask my general practitioner for?
Re:Chloroquine has shown apparent efficacy in treatment of C... by jandrewrogers on Tuesday March 17, 2020 @12:25AM (#22601658)
This class of drug is a prophylactic for malaria. It, or one of its equivalents, is commonly given to you if you tell your doctor that you are traveling to a part of the world where malaria is currently endemic. It isn't the kind of drug where they worry much about abuse or misuse, as it is cheap and ubiquitous in the developing world.
Re:Chloroquine has shown apparent efficacy in treatment of C... by WilsonPaige on Monday March 16, 2020 @11:35PM (#22601370)
A doctor can prescribe it. Best to take it under the supervision of a doctor.
Re:Chloroquine has shown apparent efficacy in treatment of C... by petecox on Monday March 16, 2020 @11:57PM (#22601503)
It's commonly used for malaria. A related '-quine' is the active ingredient of Gin and Tonic.
Re:Chloroquine has shown apparent efficacy in treatment of C... by Udik on Tuesday March 17, 2020 @12:07AM (#22601547)
The active ingredient of gin & tonic is definitely alcohol :)
Re:Chloroquine has shown apparent efficacy in treatment of C... by IAmEveryone on Tuesday March 17, 2020 @01:15AM (#22601933)
Tonic was invented to make quinine palatable to British soldiers in India. About three minutes into the scheme, someone added gin.

So quinine is indeed arguably the original “active” ingredient, sugar was second (to mask the flavor), and alcohol “let’s just pretend this isn’t happening” was third.

Re:Chloroquine has shown apparent efficacy in treatment of C... by elric on Tuesday March 17, 2020 @07:28AM (#22603795)
Is this the same malaria drug that can cause depression and lead to suicidal thoughts?
Re:Chloroquine has shown apparent efficacy in treatment of C... by toomanybeersies on Monday March 16, 2020 @11:42PM (#22601412)
GPs won't prescribe on the basis that you might get sick and require a particular medication. You can't walk into your GP's office and ask for antibiotics, for instance.
Re:Chloroquine has shown apparent efficacy in treatment of C... by inferiorhuman on Monday March 16, 2020 @11:50PM (#22601456)
That's pretty much the exact set of circumstances that chloroquine is usually prescribed under.
Re:Chloroquine has shown apparent efficacy in treatment of C... by toomanybeersies on Tuesday March 17, 2020 @02:38AM (#22602358)
My mistake, I didn't realise chloroquine was a malaria prophylactic (I've always been given other anti-malarials), I thought it was only a treatment for when you were actually diagnosed with malaria.
Re:Chloroquine has shown apparent efficacy in treatment of C... by cbhl on Monday March 16, 2020 @11:59PM (#22601513)
Under normal times, if you tell your doctor that you're planning on traveling, sometimes they'll ask if you want anti-malaria medication, and I believe chloroquine is one of the options they give you.
Re:Chloroquine has shown apparent efficacy in treatment of C... by jcims on Tuesday March 17, 2020 @12:21AM (#22601630)
Yes my daughter got it on a trip to Tanzania last year.
Re:Chloroquine has shown apparent efficacy in treatment of C... by Khelavaster on Tuesday March 17, 2020 @09:27AM (#22604650)
Then you should go after the doctor for malpractice because malaria in East Africa is hydrochloroquine-resistant.
Re:Chloroquine has shown apparent efficacy in treatment of C... by jcims on Tuesday March 17, 2020 @05:42PM (#22610778)
That’s the least bit of malpractice I’ve seen in the past year.
Re:Chloroquine has shown apparent efficacy in treatment of C... by hnick on Monday March 16, 2020 @11:41PM (#22601406)
That is good news. But why 3-4 days? Because once it settles in the lungs it's out of reach for both treatments?

And do you mean 3-4 days from the appearance of symptoms or from the initial infection? From what I read, 3-4 days is not always long enough for someone to even know they have it.