Re:Chloroquine: An Effective Treatment for Coronavirus
by Merrill on Monday March 16, 2020 @05:13PM
(#22597909)
Chloroquine Prevention of Coronavirus Disease (COVID-19) in the Healthcare Setting (COPCOV)
Sponsor: University of Oxford
The study is a double-blind, randomised, placebo-controlled trial that will be conducted in health care settings. After obtaining fully informed consent, the investigator will recruit healthcare workers, or other individuals at significant risk who can be followed reliably for 5 months. 10,000 participants will be recruited and the investigator predict an average of 200 participants per site in 50 sites.
UK bans parallel export and hoarding of three Covid-19 drugs
By GlobalData Healthcare
SHARE
The UK government has banned the parallel export and “hoarding” of three drugs being used to treat coronavirus patients in China in anticipation of shortages in Britain following the Covid-19 pandemic.
The export of the US-based AbbVie’s Kaletra / Aluvia, a combination lopinavir and ritonavir, the generic drug chloroquine phosphate and the generic drug hydroxychloroquine is being restricted to meet the needs of UK patients, the government said.
Hydroxychloroquine was placed on the restricted list from 14 March and Kaletra and chloroquine phosphate were added on 26 February.
Re:Chloroquine: An Effective Treatment for Coronavirus
by kiterunner2346 on Tuesday March 17, 2020 @12:38PM
(#22606758)
Why did you delete most of wilsonpaige's posts? All he did is put two things together and come up with an idea that will apparently work. So he's kinda in Neils Bohr's situation with the hydrogen atom: it works, it only works here, I don't know why it works, but it works! Isn't that the essence of creativity?
Why the dunning and shunning? If the women in reasonable shoes on this bbs had any creativity we wouldn't be in a jam with Covid.
Is wilsonpaige so different in this regard from Elon Musk? Musk posts re quinone and is praised and his ideas spread. Wilsonpaige at first doubts the quinone solution, then within hours finds confirming studies, adds to it his experience with zinc antivirals and comes up with a better solution (albeit one w/o an underlying mechanism). Now you've torn his posts up and thrown them away.
Re:Chloroquine: An Effective Treatment for Coronavirus
by WilsonPaige on Monday March 16, 2020 @05:22PM
(#22598015)
Opposing statement by a Ghanian doctor and director of public health:
"Dr. Badu Sarkodie, the Director of Public Health, Ghana Health Service (GHS), says they have no evidence that Chloroquine Phosphate 250mg is an effective treatment of the flu-like coronavirus (COVID-19).
He was reacting to claims on social media that Chloroquine Phosphate 250mg had been found by French and Chinese doctors to be effective for treatment of the virus.
Dr. Sarkodie in an interview with the Ghana News Agency (GNA) said although the claim sounded promising, the GHS had not had any efficacy clinical trial to confirm that.
They could therefore not make any recommendation for the use of the drug to treat the virus.
"I cannot dispute the claim so the person saying this should provide more information because we have not sighted any publication to this effect," he added."
Re:Chloroquine: An Effective Treatment for Coronavirus
by Engineering-MD on Monday March 16, 2020 @07:48PM
(#22599618)
Just in case anyone gets drawn into this, all the above is not based on any evidence. The poster has literally made up a ‘protocol’ that sounds right.
Chloroquine is under current investigation (ie results not yet in, and certainly not a treatment protocol) and zinc has been shown in some cases to maybe improve some aspect of illness, it’s far from proven.
The rest of what they said is at best speculation/conjecture.
DIY on zinc - There is an entire industry of antiviral zinc sprays, lozenges and pills. Zinc stops viral replication deader than your prefrontal lobes:
Re:Chloroquine: An Effective Treatment for Coronavirus
by WilsonPaige on Monday March 16, 2020 @11:02PM
(#22601182)
Whoa! Put the flag down! If you look at my history in my profile you'll see that I _anticipated_ your questions about the chloroquine phosphate studies but now been provided enough information so that I do not doubt that chloroqine phosphate is a very good treatment (in conjunction with zinc).
Some links for Chloroquine phosphate:
"Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies":
L.A.Times article with links (feel free to chase the links yourself) that gives more detail about the above paper cited:
"A more unorthodox remedy being tested against the coronavirus in China is chloroquine.
The drug is intended to treat malaria, a condition caused by a parasite transmitted through a mosquito bite. A limited number of studies suggest the drug can work against SARS. In laboratory tests, it kept COVID-19 from spreading by blocking its method of infecting cells, according to a report last week in the journal Cell Research."
The Chinese source re chloroquine, was posted on ycombinator by sp332 3 hours ago (I quote him below):
"This summarizes the results of a bunch of trials that were run in parallel in China."
You can do your own search for information on the effects of zinc on viruses and in particular corona viruses - it's old story (dating back to circa 1970s at least), the results have created a entire industry of zinc-related products (zicam et al).
Sponsor: University of Oxford
The study is a double-blind, randomised, placebo-controlled trial that will be conducted in health care settings. After obtaining fully informed consent, the investigator will recruit healthcare workers, or other individuals at significant risk who can be followed reliably for 5 months. 10,000 participants will be recruited and the investigator predict an average of 200 participants per site in 50 sites.
https://clinicaltrials.gov/ct2/show/NCT04303507
UK bans parallel export and hoarding of three Covid-19 drugs
By GlobalData Healthcare SHARE The UK government has banned the parallel export and “hoarding” of three drugs being used to treat coronavirus patients in China in anticipation of shortages in Britain following the Covid-19 pandemic.
The export of the US-based AbbVie’s Kaletra / Aluvia, a combination lopinavir and ritonavir, the generic drug chloroquine phosphate and the generic drug hydroxychloroquine is being restricted to meet the needs of UK patients, the government said.
Hydroxychloroquine was placed on the restricted list from 14 March and Kaletra and chloroquine phosphate were added on 26 February.
https://www.pharmaceutical-technology.com/comment/parallel-e...
(A reminder that Musk is not an expert on virology.)
"Coronavirus Chloroquine & Zinc Treatment":
https://citycourier.org/news/coronavirus-chloroquine-zinc-tr...
Why the dunning and shunning? If the women in reasonable shoes on this bbs had any creativity we wouldn't be in a jam with Covid.
Is wilsonpaige so different in this regard from Elon Musk? Musk posts re quinone and is praised and his ideas spread. Wilsonpaige at first doubts the quinone solution, then within hours finds confirming studies, adds to it his experience with zinc antivirals and comes up with a better solution (albeit one w/o an underlying mechanism). Now you've torn his posts up and thrown them away.
Shame!
"Dr. Badu Sarkodie, the Director of Public Health, Ghana Health Service (GHS), says they have no evidence that Chloroquine Phosphate 250mg is an effective treatment of the flu-like coronavirus (COVID-19).
He was reacting to claims on social media that Chloroquine Phosphate 250mg had been found by French and Chinese doctors to be effective for treatment of the virus.
Dr. Sarkodie in an interview with the Ghana News Agency (GNA) said although the claim sounded promising, the GHS had not had any efficacy clinical trial to confirm that.
They could therefore not make any recommendation for the use of the drug to treat the virus.
"I cannot dispute the claim so the person saying this should provide more information because we have not sighted any publication to this effect," he added."
Chloroquine is under current investigation (ie results not yet in, and certainly not a treatment protocol) and zinc has been shown in some cases to maybe improve some aspect of illness, it’s far from proven.
The rest of what they said is at best speculation/conjecture.
https://www.ncbi.nlm.nih.gov/pubmed/32074550
DIY on zinc - There is an entire industry of antiviral zinc sprays, lozenges and pills. Zinc stops viral replication deader than your prefrontal lobes:
https://duckduckgo.com/?q=zinc+halts+viral+replication&t=ope...
Like I said, we have herein a safe treatment that is cheap, available, and free of risk, namely
1. immediate zinc lozenge/spray/pill dissolved in mouth to be applied early (preferably first 3 days) of illness, and possibly every day thereafter +
2.Chloroquine phosphate (up to 500 mg/day).
Otherwise, I'll continue to flag posts like this.
Some links for Chloroquine phosphate:
"Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies":
https://www.ncbi.nlm.nih.gov/pubmed/32074550
https://www.latimes.com/science/story/2020-02-13/fighting-co...
L.A.Times article with links (feel free to chase the links yourself) that gives more detail about the above paper cited:
"A more unorthodox remedy being tested against the coronavirus in China is chloroquine.
The drug is intended to treat malaria, a condition caused by a parasite transmitted through a mosquito bite. A limited number of studies suggest the drug can work against SARS. In laboratory tests, it kept COVID-19 from spreading by blocking its method of infecting cells, according to a report last week in the journal Cell Research."
The Chinese source re chloroquine, was posted on ycombinator by sp332 3 hours ago (I quote him below):
https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/...
"This summarizes the results of a bunch of trials that were run in parallel in China."
You can do your own search for information on the effects of zinc on viruses and in particular corona viruses - it's old story (dating back to circa 1970s at least), the results have created a entire industry of zinc-related products (zicam et al).