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Re:Open letter from Italy to the international scientific co... by cameldrv on Sunday March 15, 2020 @03:36AM (#22581997)
Can you cite a source? Current Chinese treatment guidelines allow it.

Also very important to quantify side effect risks, even if it's a rough estimate. For example, if a 70 year old patient has already progressed to dyspena, they might have something like a 20% mortality rate from COVID. Even if there is a side effect profile for the treatment that normally would be considered very dangerous, it may be well worth it to administer it.

We see the same thing with chemotherapy or radiation treatment. The side effects are terrible and fairly often fatal, but they are safer than the disease. This is the situation in which we find ourselves.

Re:Open letter from Italy to the international scientific co... by copperx on Sunday March 15, 2020 @03:58AM (#22582072)
I can't find the original source, but you can easily verify that both drugs increase the QT/QTC and PR interval, which is a high-risk interaction AFAIK (I'm not a doctor). Some doctors recommend doing an EKG before administering Chloroquine.

https://www.sciencedirect.com/science/article/pii/S088394412...

What you're saying is true, but you're assuming that Chloroquine + Kaletra is better than Chloroquine by itself, and we don't have the data for that yet.

Do you have a source for the Chinese recommendations?

Re:Open letter from Italy to the international scientific co... by cameldrv on Sunday March 15, 2020 @04:39AM (#22582210)
Thanks for the link. Current Chinese treatment guidelines are: https://www.chinalawtranslate.com/en/coronavirus-treatment-p...

They state:

4. Antiviral therapies: Interferon-alpha (adult: 5 million units or equivalent can be added to 2ml sterile injection water and delivered with a nebulizer twice daily), lopinavir/ritonavir (adult: 200mg/50mg/tablet, 2 tablets twice daily; the length of treatment should not exceed 10 days), ribavirin (recommended in combination with interferon or lopinavir/ritonavir, adult: 500mg twice or three times daily via IV, the length of treatment should not exceed 10 days), chloroquine phosphate (adult 18-65 years old weighing more than 50kg: 500mg twice daily for 7 days; bodyweight less than 50kg: 500mg twice daily for day 1 and 2, 500mg once daily for day 3 through 7); umifenovir (adult: 200mg three times daily; the length of treatment should not exceed 10 days).

Pay attention to issues such as adverse drug reactions, contraindications (for example, chloroquine should not be given to patients with heart diseases), and drug interactions. Further evaluate the efficacy of current treatment regimens in clinical applications. Using 3 or more antiviral drugs is not recommended. Corresponding medication should be discontinued should intolerable side effects appear.

Re:Open letter from Italy to the international scientific co... by Cantbekhan on Sunday March 15, 2020 @06:10AM (#22582522)
Same for many EU guidelines

Source as I posted on other submissions

Chloroquine is mostly admitted as a valid treatment now

https://news.ycombinator.com/item?id=22582374