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Re:Disqus: Scaling the World’s Largest Django Application by ruckusing on Wednesday February 23, 2011 @02:30PM (#2255399)
I've found "Scalable Internet Architetures" by Theo Schlossnagle to also be quite valuable. It contains general advice on how to approach problem solving when it comes to building uh, scalable architectures.

http://www.amazon.com/Scalable-Internet-Architectures-Theo-S...

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