Very surprised to see that reproduction cost was <<10% of total budget. I would assume that this would only hold for small scale biology with low variable costs and standard equipment like in vitro cell biology and computational work. A different financial approach is likely necessary for setups with high variable and fixed costs (e.g. animal and human work). Not saying it shouldn't be a required part of the funding but the speed of science changes if you need to spend 50% of your budget on reproduction.