SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockable by protease inhibitor

Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by biolurker1 on Friday March 06, 2020 @09:28AM (#22503793)

I also got chloroquine but I think I would use it on my parents or me only if we would be sick for a long time without ER room or something. What's your plan?

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by rscho on Friday March 06, 2020 @10:50AM (#22504491)

That's a f###ing bad idea given the current state of knowledge about this infection. Your chance for doing more harm than good is huge.

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by biolurker1 on Sunday March 08, 2020 @09:25AM (#22517894)

why? that's a drug that has been used, and honestly if my parents are 20 days in trouble breathing and ER is full I can't see why not. Other choice is to let them die

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by rscho on Tuesday March 10, 2020 @11:48AM (#22536451)

It amazes me how people can be most defiant regarding usual care practice and so prompt at accepting the first hypothetical unverified claim that comes their way in an emergency. Truly dumbfounding. And I've been at it for more than 10 years already.

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by biolurker1 on Wednesday March 11, 2020 @04:30AM (#22544115)

https://www.ncbi.nlm.nih.gov/pubmed/32150618

This can change your mind

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by rscho on Wednesday March 11, 2020 @07:27AM (#22544856)

You mean the "in vitro" part?

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by biolurker1 on Wednesday March 11, 2020 @12:20PM (#22547028)

I mean it's common practice at hospitals now. Using dumbfounded dumb dumb words is dumb bro

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by rscho on Thursday March 12, 2020 @06:24AM (#22555337)

Bro understands the difference between "non-peer-reviewed chinese study over 100 patients" and "lifesaving treatment" bro. Because bro happens to do clinical research for a living, bro.

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by biolurker1 on Thursday March 12, 2020 @07:11AM (#22555562)

Let's see what you do when your spouse is dying in your apartment with no medical help and all you have is a box of chloroquine. I truly don't wish this for you.

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