SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockable by protease inhibitor

Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by rscho on Friday March 06, 2020 @06:43AM (#22502832)

Yes... well-studied does not mean without drawbacks.

Right now on this day, OP is probably more likely to die from chloroquine administration than from the pandemic.

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by jamesblonde on Friday March 06, 2020 @07:24AM (#22503026)

I dont think chloroquine has 3% morbidity. And if you are a higher risk individual, the math towards chloroquine improve. By dosing in a controlled ramp-up way, you can better mitigate many known side effects such as psychosis - identify earlier and most cases resolve when treatment is ceased.

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by rscho on Friday March 06, 2020 @08:06AM (#22503234)

3% is as good as a number drawn from a hat at this stage of the epidemic, be it drawn from Nature, Cell or whatever. Also, those 3% assume you are contaminated. You can't compare that to a short-to-medium term run of preventive chloroquine adminstration, which has a rather high incidence of minor side effects.

You are statistically comparing oranges to apples. This behaviour increases your risk of hurting yourself by a large margin compared to simply following WHO recommendations.

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by jamesblonde on Friday March 06, 2020 @09:15AM (#22503701)

I don't disagree with you, actually. Like I said, if you are in a high risk group, the math changes - but I agree that mass preventive chloroquine adminstration would not be a good idea. However, if there is a large outbreak, shortages of chloroquine or you have to wait days/weeks for your doctor to prescribe chloroquine - that is not a place i personally want to be.

On another note, this is a nice thread helping me (and maybe others) inform them about side effects and efficacy of possible treatments.

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by angry_octet on Friday March 06, 2020 @08:41AM (#22503431)

Statistically, population wide chloroquine prophylaxis would probably cause more problems than is warranted by the COVID-19 threat.

Even if it works, and isn't just wishful thinking / propaganda.

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by rscho on Friday March 06, 2020 @08:44AM (#22503446)

I agree.

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by hexl on Friday March 06, 2020 @07:00AM (#22502918)

Bleach has a well studied safety profile too

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by blattimwind on Friday March 06, 2020 @07:49AM (#22503158)

Kills cancer, prevents caries

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by DanBC on Friday March 06, 2020 @07:11AM (#22502964)

https://bnf.nice.org.uk/drug/chloroquine.html

> Side-effects

> Rare or very rare

> Cardiomyopathy; hallucination; hepatitis

>Frequency not known

> Abdominal pain; agranulocytosis; alopecia; anxiety; atrioventricular block; bone marrow disorders; confusion; corneal deposits; depression; diarrhoea; eye disorders; gastrointestinal disorder; headache; hearing impairment; hypoglycaemia; hypotension; insomnia; interstitial lung disease; movement disorders; myopathy; nausea; neuromyopathy; neutropenia; personality change; photosensitivity reaction; psychotic disorder; QT interval prolongation; seizure; severe cutaneous adverse reactions (SCARs); skin reactions; thrombocytopenia; tinnitus; tongue protrusion; vision disorders; vomiting

This "frequency not known" is listed alphabetically. There's some potentially fatal things in that list.

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by biolurker1 on Friday March 06, 2020 @09:24AM (#22503756)

have you tried reading paracetamol leaflet under the frequency not known paragraph?

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Re:SARSCoV2 cell entry depends on ACE2 and TMPRSS2, blockabl... by refurb on Friday March 06, 2020 @01:53PM (#22506180)

Billions of people take paracetamol with no issues at all. That's not true about chloroquine.

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