Here is what I'd add for it:

I don't care if you're make or female, people need to improve constantly in 3 parameters for their whole life-span:

1. Looks (basically proper nutrition and some degree of bodybuilding training)

2. Psychological strength

3. Affluence

You need a life meaning mission that makes you feel good at improving these, using that mission as the vehicle. If you can do that, you'll be an example and all the rest will fall into place.

If you unbalance these, you'd be screwing up and diminishing the overall life-satisfaction returns.

Startups, or business, in general, are only going to (when they work) improve affluence and (always) consume psychological strength.

Proper nutrition and going to the gym (and I mean lifting HARD) falls into improving looks which also helps in relieving psychological and physical stress.

If you break that delicate balance you're investing in some kind of deformed creature that will eventually show. Hence, this kinds of depression wouldn't be a surprise to emerge as a manifestation of breaking that sustainable self-improvment equation.