The Quest might be the best one to test for travel though; it's relatively cheap, has fairly good resolution, and though it normally works as a standalone system, you can also tether it over USB3 to your main machine's graphics card:
https://www.anandtech.com/show/15135/oculus-link-software-av...
The first time I used Simula, I did experience fatigue. After that, it seemed to go away. I tend to use it for a few hours at a time, so cannot comment beyond that, but it seems to work pretty well.
If you're interested in giving Simula a try, contact me at george.w.singer [at] gmail [dot] com. Right now, it's only compatible with the HTC Vive, HTC Vive Pro, or Valve Index. It should otherwise be buildable/runnable on all Linux distros.
In games, no. With desktop usage, yes.
With a setup like that is there any fatigue after a few hours of usage ?