there are structural conformations that are not indicated-

you must exploit a biological system that will create a functional virion-

before you do that , if you understand genodynamics of the sequence you can start making good guesses about where to change the sequence in what way-

this can be because you want attenuation of the virus with an extreme degree of control-

this is how you make a recombinant product that is not as damaging to the host and produces a strong antigenic signal to the immune system this means you have a vaccine-

of course this is also a dualpotential technology so it could be used for evil and weaponized, so we want to have some inspection regarding who has these opportunities