Yes, in fact ublock origin has a very advanced global/local case where you can block resources globally or block resources locally and temporarily if you really want.

It's generally better to use ublock origin on it's own than to use ublock origin with umatrix or ublock with noscript. Mainly because ublock origin comes wiht neutralising anti-adblock scripts that would get blocked if you combine it with a separate script blocker.

https://www.reddit.com/r/firefox/comments/706xrr/umatrix_vs_...

Here is a good tutorial on how to use ublock origin in advanced mode.

https://www.youtube.com/watch?v=2lisQQmWQkY