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A comment on Remdesivir and chloroquine effectively inhibit coronavirus (2019-nCoV) in vitro. Parent comment

Re:Remdesivir and chloroquine effectively inhibit coronaviru... by EForEndeavour on Wednesday February 26, 2020 @11:33PM (#22430484)
This is an example of real-world evidence (https://en.wikipedia.org/wiki/Real_world_evidence), gathered outside the context of any kind of drug trial, blinded or not.

While these two outcomes may not achieve statistical significance in the mathematical sense...

- there are compelling mechanistic hypotheses for why the treatments might work

- drug doses are being supplied for free by manufacturers

- infected people don't have the luxury of time to wait for RCT results

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Re:Remdesivir and chloroquine effectively inhibit coronaviru... by AstralStorm on Thursday February 27, 2020 @07:37AM (#22432678)
Most importantly, a placebo controlled RCT would be unethical for a disease with high mortality rates.

You would run a randomized controlled trial with treatment control (not placebo controlled) when we have an effective treatment. These are about as good as it is assumed placebo effects figure the same in all tested treatment groups.

[ Parent | on HN ]