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A comment on Human gut bacterial enzyme ingests L-dopa and converts it to dopamine.

Re:Human gut bacterial enzyme ingests L-dopa and converts it... by hinkley on Thursday February 20, 2020 @07:15PM (#22379869)
I wonder how many drug studies we'll end up having to eventually re-do to account for metabolic interference by microbes.

Everyone without this microbe was non-responsive to Drug A. Everyone with this microbe had negative outcomes from Drug B.

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Re:Human gut bacterial enzyme ingests L-dopa and converts it... by LARP1234 on Thursday February 20, 2020 @07:58PM (#22380097)
Likely none.

The paper describes finding an enzyme that can cleave catecholamine precursors. OK? There's literally only one catecholamine precursor that's used medically, and that's L-DOPA.

We know Parkinson's medications work, and very effectively. L-DOPA is used effectively, despite being metabolized by gut flora.

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Re:Human gut bacterial enzyme ingests L-dopa and converts it... by sjg007 on Thursday February 20, 2020 @07:26PM (#22379931)
I think many. Maybe not a negative effect but no effect.
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