A transpiler is a compiler. There's nothing that can be compiled but can't be transpiled, because transpiling is just what we call compiling when the target is subjectively deemed a high-level language. So the problem you're describing isn't with transpilation; it sounds like it's with compiling a dynamic language with reflection. That's a tractable problem; you just can't solve it as statically as you would for an AOT-compiler for a more analyzable language. Reflection has to be as late-bound as the rest of the language.