I have two identical setups, both with two 27 monitors and to make it worse one is horizontal and one vertical. Most of the time when i go to the other desk the monitors switch and I have to reset the orientation in display preferences. I have been fighting this for two years. Reset everything apple has told me to and no fix at all. Total PIA.

Tried 3rd party app "SwitchResX"?

It's not the resolution it's the orientation that keeps getting flipped.

--- Well I take that back. It's been updated since last i used it a few years ago. There is display orientation savings now. It might now solve the problem, but it sure looks to make the fix much easier and faster. Trying it now. Thanks

Same issue for dual display setup, my workaround is to label the cables and make damn sure I plug them in the same order and same port every time. If I do it wrong I’ve to do the display settings and rotate both screens routine..

Another option is to use the left side ports at work and the right side at home.

Ports works SOMETIMES but since all 4 monitors are identical i still see confusion. I may try the left/right though. Currently all cables are hidden so i'll have to redo some to pull that off.

I commonly do this (hot desking) and don’t have the issue.