If I'm working on client work, then I always do wireframes first (giving a choice of three different layout/UX concepts). But for WIL, because I was working for myself and under a self imposed time constraint, I went straight from sketches --> PSDs --> CSS.

I'm going to be revamping the profile pages in the near future, and that process will almost certainly include wireframing, since I have more time to do it "right".