I use Muted Words and block accounts liberally, to scorch-earth anything that might possibly be adjacent to anything political. This filters probably 90% of what I would otherwise encounter. I don't delete my account because it's a uniquely vibrant resource for game dev and digital art, two of my hobbies.

The actual people I follow are generally really nice; it's just the people they occasionally retweet and then the replies that other people make to those retweets that get into the mud.