Re:What's Happening with the Coronavirus
by romanhotsiy on Tuesday February 04, 2020 @08:49AM
(#22235451)
> We also noticed that the only Asian donor (male) has a much higher ACE2-expressing cell ratio than white and African American donors (2.50% vs. 0.47% of all cells). This might explain the observation that the new Coronavirus pandemic and previous SARS-Cov pandemic are concentrated in the Asian area.
the only Asian donor, n=1. It's too bold to claim that Asian men are the most susceptible group.
Current estimated death rate is 15% (based on now slightly out-of-date Lancet articles).
Asian men are the most susceptible group.
Male / female infection rate currently about 3:1 (but based on low statistics).
Ratio of ACE2 cells in Asian men to Asian women is about 4:1.
Ratio of ACE2 cells in Asian men compared to whites or African-Americans is 5:1.
https://www.biorxiv.org/content/10.1101/2020.01.26.919985v1....
See some criticisms of the methods and results in the comments. Interesting correlation of ACE2 to stress and high blood-pressure, so could be strongly affected by some treatments for hypertension.
It is just about possible, in some qualitative hand-waving way, that reducing susceptibility by 80% could drop R0 from 5 to 1, hence reduce the threat of an epidemic in other regions.