Yes for me when making large prints. You don't get good prints at less than 150 dpi enlarged, generally, and 300+ dpi is preferable and more comparable to a large format negative, so you'd like a ~75 megapixel camera just for poster sized prints, and more for prints larger than that.

Note some people use large format negatives for ultra-sharp small prints, in that case you might be looking for 1000 dpi or higher to match the fidelity of a large negative.