You run collectstatic to get all of your static assets in one folder, use gunicorn (python package, there are other options as well such as uwsgi) to serve your wsgi server, and have nginx in front of gunicorn to intercept anything with /static/* to pull from your static assets folder. This is all 3 or 4 lines of config in nginx.

Your first try might take a couple of hours to get right. If you want HTTPS (you should) Caddy might be a better route than nginx. It's certainly easier.