Novel coronavirus complete genome from the Wuhan outbreak available in GenBank

Re:Novel coronavirus complete genome from the Wuhan outbreak... by nestorD on Tuesday January 28, 2020 @02:51AM (#22167295)

I found out a few days ago when an, interesting, related question was posted on bioinformatics.stackexchange.com : Why does the Wuhan coronavirus genome end in aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa (33 a's)? [0]

[0]: https://bioinformatics.stackexchange.com/questions/11227/why...

[ Parent | on HN ]

Re:Novel coronavirus complete genome from the Wuhan outbreak... by sumgocko on Tuesday January 28, 2020 @08:09AM (#22168986)

(This is baseless speculation by someone who has only taken Genetics 101)

Human cell nuclei produce mRNA from DNA, which then makes it's way to the ribosome to be expressed as a chain of amino acids, or a protien. On it's way to the ribosome, it needs protection from the cell's RNA cleanup enzymes, so it leaves the nucleus with a 5' cap and a poly-A tail.

Therefore, it makes sense that a virus that wishes to hijack human ribosomes would end in a poly-A tail (a bunch of As) in order to not get destroyed by human cells.

[ Parent | on HN ]

Re:Novel coronavirus complete genome from the Wuhan outbreak... by gexla on Tuesday January 28, 2020 @04:56AM (#22167917)

Reminds me of the skit about the Monty Python creature of the name "The Black Beast of Aaaaaaargh."

[ Parent | on HN ]

Re:Novel coronavirus complete genome from the Wuhan outbreak... by signal_space on Tuesday January 28, 2020 @08:47AM (#22169275)

https://en.m.wikipedia.org/wiki/Polyadenylation

[ Parent | on HN ]

Re:Novel coronavirus complete genome from the Wuhan outbreak... by flatiron on Tuesday January 28, 2020 @07:19AM (#22168665)

Nop slide

[ Parent | on HN ]

Re:Novel coronavirus complete genome from the Wuhan outbreak... by zedr on Tuesday January 28, 2020 @09:14AM (#22169520)

Padding?

[ Parent | on HN ]