Re:FDA approves first US phage therapy trial (2019)
by chmod775 on Monday January 27, 2020 @10:39PM
(#22166223)
Took me a while to dig up an online source of his 1921 monograph on the subject. For the curious:
https://archive.org/details/lebactriophages00hrgoog/page/n9/...
(PDF etc. downloads are at the bottom right)
Re:FDA approves first US phage therapy trial (2019)
by Fomite on Monday January 27, 2020 @10:44PM
(#22166248)
If you're interested, Flemming's Nobel Prize speech transcript is here: https://www.nobelprize.org/uploads/2018/06/fleming-lecture.p...
It's an excellent read.
But you will find on that same Wikipedia page an entry for d'Herelle, and if you follow that...as you note yourself, you get an animal trial in 1919 as well as a human trial. D'Herelle then heads to Indochina to work on Cholera, and he's awarded an honorary doctorate two years after the USSR is founded - along with one of the field's most prestigious medals.
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Is that a tight timeline? Yes. But the idea that "The West" ignored phages because it was some sort of Soviet pseudoscience is contrary to the historical record.
The west abandoned phage therapy because unfiltered endotoxins made phage therapy dangerous, and until the modern era, antibiotics are pretty superior in nearly every respect.