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Re:Seq – A Language for Bioinformatics by snackematician on Tuesday January 21, 2020 @01:27PM (#22109815)
To expand on this -- I believe pysam [0] is the official htslib interface for Python.

It's quite good. In addition to providing Python bindings, it also provides extra functionality from within Cython, if you need additional features/speed but don't want to drop all the way down to C.

[0] https://pysam.readthedocs.io/en/latest/

Re:Seq – A Language for Bioinformatics by mbreese on Tuesday January 21, 2020 @04:28PM (#22111803)
Is the pysam API more stable now? Years ago, I had to stop using it because the API has changed between versions too much.