> Principal investigators are notoriously stubborn about how they do things

I've come across things a simple as "I wrote a Perl script that does that, but it uses KEGG not GO terms" for their reasoning. That, or – if they're okay with using gene ontology – we have to also use the other system in parallel. And then the results becomes a discussion of how the two different annotation systems display the results.

Life science could use a benevolent dictator.