Re:Progress of anti-aging therapies by clinical trial stage
by dnhz on Sunday January 19, 2020 @02:03AM
(#22089909)
The body forms structures over the course of development. But I don’t think it can replay those actions again. In places like the knee and eye lens, the cells that formed those structures did their job and dissolved their nuclei. I’m more familiar with the eye lens example so let’s go with that. The cells there are just bags of proteins and antioxidants. No nuclei, no mitochondria, no activity. Oxidation from the environment gradually damages those proteins and lead to cataracts. Everyone would eventually get cataracts if they could live forever.
DNA is not enough. There was coordination in time and space to construct the body during development, and the growing body has no damaged cells and structures to deal with.
Re:Progress of anti-aging therapies by clinical trial stage
by naasking on Sunday January 19, 2020 @08:59AM
(#22091444)
Eye damage repair:
https://www.biorxiv.org/content/10.1101/710210v1
Also, the cornea does heal from some damage, so clearly it's not just passive tissue.
I'm honestly mystified why this would be a mystery. Your cells have the blueprint to grow a whole new body, but clearly many of these pathways are dormant. Is it really so far fetched that a drug could reactivate some of these pathways?
Like, why is there a loss of hair in the ear when for the first few years of life, that hair grows instead of dies? There is even evidence that age reversal can and has been done:
https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13028
https://www.sciencedirect.com/science/article/pii/S009286741...