> Increasing lifespan more than that requires an entirely new paradigm or class of therapeutics. Like you said, we'll need entirely new biological/genetic technology to address the system-wide mutation and degradation of the body that inevitably occurs through the progression of time.

That's exactly what the drugs being discussed in this thread purportedly do. For instance, NMN allegedly repairs epigenetic factors that repair DNA damage, but which degrade as we age.