On the other hand, this suggests there are low-hanging fruit in those areas.

The trick is to find one that will produce money for you as a researcher/investor even if it's an unpopular opinion (i.e. not reliant on investment / cooperation from mainstream players).

Suggestions?

Related, what's the best way to short cancel-culture-heavy endeavors? Seems like it predicts a much higher chance of failure in the long term.