The problem is time and experience, two things you cannot give to a software mind. Humans are inherently social and our brains are developed over socializing time. Our brains are shaped by fetal, post-natal, and childhood socialization and experience. The craziest edge cases of human childhood show: if you grow up without socialization, in isolation/solitude, your brain will be vastly underdeveloped and you will have very serious personality deformation.

So no, I don't think it's possible to create a simulated brain that behaves similarly as a human, as the biological medium is in a constant state of dissolution, repair, evolution, and adaptation. This is how we learn, get stressed, get tired, get certain emotions...it's a whole new layer of programming you'd need to perfect beyond just replicating a brain at one moment in time.

A brain in silico would be apples:oranges different than a biological brain.