The world will not write code for screen readers. How about writing screen readers that can read the code that the world wants to write?

That would be fantastic. The problem is that we're pretty much stuck with the screen readers we've got - even when the screen reader companies do release new versions (which they do painfully infrequently) most of their users stick with their current versions because the upgrades are so expensive. If you care about blind users (which you should; you're missing one of the great benefits of the Web if you don't) you need to cater to screen reader versions that are five or so years old!

Fine, I'll ignore the blind market. I'm not trying to be mean but just realistic. I don't operate a government website which needs to be ADA compliant, and if screen reader software isn't where it needs to be, then maybe there is just no solution.

It is pretty pointless to care about blind users, since they can't use most AJAX based sites anyway.

I thought this was the whole point behind "graceful degradation". If an AJAX based site does not degrade to still be useable/accessible when JS is off or unavailable, then it's not that well desgined to begin with.