I don't know, I find it quite amusing when the engineer kind of ask the question in a "ohhh ummm, another interview question.... oh yea, *chuckles, this one" way. Giving a honest answer where I detail my relevant weakness while also addressing how I usually mange/compensate for it have often lead to some relaxing tension in the interview.

If it comes from a HR person, the above attitude only backfires, but I don't want to work at a place with such a heavy HR filter put on everyone anyway.