The mushrooms fixed him for 2 or so months. During that time he should have woken up and sorted his life out. Thats enough time to start exercising, having the conversations at home and work.
You dont have to solve everything all at once, but fixing depression is a cumulative process where even small changes in diet, exercise and environment will compound over time and put you in a better place.
The mushrooms will show you the answer, but it's up to the individual to act.
Did you notice in his post he didn't describe what happened when he was cured in those two months? No, straight back to finger pointing and blaming everyone else.
He needs to hear the blunt truth : maybe, just maybe, it's his fault. Then he can take more mushrooms and work on fixing it, rather than expecting them to be a magic bullet.
In my observation the perpetually depressed are often (no, not always, but very often) home bodies who barely leave their domicile and spend ample amounts of time on social media, staying up late mindlessly scrolling through their phones. There are simple but perhaps difficult changes to be made here.