How an Alzheimer’s ‘cabal’ thwarted progress toward a cure

Re:How an Alzheimer’s ‘cabal’ thwarted progress toward a cure by michaelbarton on Monday December 30, 2019 @08:12AM (#21913101)

I agree, that's fair. I don't think it's an explicit conspiracy. However there are some practices that do end up suppressing results. One particular example is that lack of publication of negative results because there is no incentive for doing so. You can imagine a scenario where similar experiments are repeated over and over again in different laboratories because no one writes up the negative result. After all what's the incentive? Not so bad for a few wasted weeks of PhD students time but potentially more damaging for large drug clinical trials?

Ben Goldacre's bad science is a great book on this topic. He's an entertaining speaker too. He describes a solution to that particular problem which is registering a clinical trials beforehand.

https://www.theguardian.com/business/2012/oct/07/ben-goldacr...

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Re:How an Alzheimer’s ‘cabal’ thwarted progress toward a cure by Certhas on Monday December 30, 2019 @09:54AM (#21913668)

Absolutely, but that's a form of self suppression, rather than a cabal of others suppressing results.

Science is incredibly broken in many ways. I think the big underlying culprit is the prevailing ideology that every human activity is best organized as a competition for scarce resources.

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Re:How an Alzheimer’s ‘cabal’ thwarted progress toward a cure by ethbro on Monday December 30, 2019 @09:10AM (#21913411)

It's a good idea: have a fully-open repository where negative results can be documented. With the ability to tag on if a negative result is replicated.

Then gradually re-enculture review boards to expect any given author to have a substantial number of results published to said repository, if they're actively performing research.

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