I do wonder if you're spreading yourself too thin and not focusing on nailing one or two jobs you're really interested in by applying to so many places. I get that it's a numbers game so I truly understand and salute the effort, but I wonder if being rejected from hundreds of jobs is pointing out that something needs to be adjusted. I recently spent a few months finding a job and landed one I'm really happy with. I'm happy to provide feedback and advice if you're interested. Contact details in my profile.

How popular is .NET in your market? Have you considered learning other technologies to enhance your skillset?

I would recommend that you attend local user group meetings and talk to people. Weak social connections are an excellent source of referrals.

Are having trouble getting interviews, getting offers, or both?