Your mileage may vary! I found it easy and rewarding, other people find the ortholinear layout confusing and struggle to type on it, as some sibling comments show.

The one hitch I hit early on, is that it turns out I type 'y' with the left finger on laptops, and on a stock ErgoDox, that involves hitting a layer button, which of course throws off one's rhythm. I had to turn that key into a dead key until I got used to typing y with my right finger (I still hit it with the left on a laptop).

Hah, the key I struggled with the most was 'b'. My brain was convinced that was a right index-finger key the first couple of weeks using an Ergodox EZ.

To be fair, most ergonomic keyboards have strange layouts. Such is the price for avoiding RSI.

The microsoft natural 4000 keyboard is pretty standard except split in the middle. It's good enough for me, no need to relearn but much better to use. I still get wrist problems but it takes longer.