> It also doesn't seem culturally aligned with the rest of the USA, so I think that would be evidence to point to it not having a big influence or impact on US culture.
I'm not sure what you mean by this, can you explain? I would actually argue the opposite. Almost all modern American culture wars have been centered around San Francisco in some way, shape, or form.
Speaking as someone who has spent their entire life on the West Coast, I almost never even think about New York or the East Coast. To me, it's the east coast that seems disconnected from reality.
I always thought Pixar was close to Oakland, not SF. Lucasfilm is a pretty good pick. But there are a lot of other higher impact studios in SoCal.
EA's talent is spread all over the globe. What games are developed in SF? I don't see how a corp HQ that mostly buys studios after they make a breakout game as a center of culture (center of power, yes. culture, no)
It doesn't seem to have a lot of production of note in the arts or media (TV, movies, games, music, books, etc).
It also doesn't seem culturally aligned with the rest of the USA, so I think that would be evidence to point to it not having a big influence or impact on US culture.