Re:Tendon stem cells enhance regeneration
by Engineering-MD on Wednesday November 27, 2019 @07:48PM
(#21653736)
As far as I am aware, the association with aortic aneurysm is weak ( I think a relative risk of 2) from an associate only study (ie no causation proven). So take these with a pinch of salt, especially for those with a penicillin allergy as covering some bugs without penicillins or flouroquinolones can be tricky.
Re:Tendon stem cells enhance regeneration
by dmead on Tuesday November 26, 2019 @02:45PM
(#21641904)
So basically it fucks with your connective tissue?
Re:Tendon stem cells enhance regeneration
by dfsegoat on Tuesday November 26, 2019 @11:16PM
(#21645190)
> The histopathologic findings [of the tendons] include degenerative lesions, fissures, interstitial edema without cellular infiltration, necrosis and neovascularization [1]
Basically it dissolves, and the achilles tendon is the most common rupture, at least with cipro.
'Do not use fluoroquinolones in patients with known aortic aneurysm, aortic dissection or history of serious side effects related to quinolone treatment (including tendon disease/disorder) unless there are no other treatment options available'
'Patients should be counselled to discontinue fluoroquinolone treatment and seek urgent medical attention at the first sign of:
- Tendon pain or inflammation (particularly in shoulder or ankle)
- Symptoms of neuropathy such as pain, burning, pins & needles, tingling, numbness or weakness
- Sudden-onset of severe and constant abdominal, chest or back pain
1. https://www.ncl-mon.nhs.uk/wp-content/uploads/Guidelines/5_F...