I think simple ads most people are OK with however you start to lose people when those ads track your movements like a creepy stalker, sell that data without your knowledge or consent, and tax your system with resource hungry js that adds precious seconds to your wait only to be served with a zero day or other malware.

Sites and ad networks have being engaged in a abusive relationship with users for a long time now and it's wrong to expect them to not try to protect themselves. If you want users to stop blocking your ads then stop serving them ads worth blocking.