I dunno about a major way, but I've had dreams which took days to properly snap back after, because the experiences felt so real that I felt an emptiness similar to bereavement for the fictional people that I dreamed about. That felt just as real to me as my experiences on DMT. I've also had Ketamine experiences that were similarly profound and have stuck with me since. Once I had a K trip which felt like I was outside of time, watching the cogs of the universe tick past instant by instant for all eternity. That experience snapped me out of a pretty depressive period of my life.
People of course have profound meaningful experiences on DMT, but I don't think its exclusive to it and any strong hallucinogen or dissociative can, in my opinion, have similarly strong impacts for some people.
Note: The experience lasts significantly longer than a non-ayahuasca DMT experience.
Curious what "high" doses of "plain old psychedelics" might be? I've never gone further than 200ug LSD.