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Re:Your throat hurts, your brain hurts: the life of the audi... by have_faith on Tuesday November 19, 2019 @05:57AM (#21571960)
Or the Japanese voice idols?
Re:Your throat hurts, your brain hurts: the life of the audi... by Filligree on Tuesday November 19, 2019 @08:20AM (#21572569)
Vocaloids?

Those are deliberately made to sound unnatural. Not to say it changes anything, and they've already shown up once or twice in anime.

(Though the only example I can name off the bat is Black Rock Shooter, and that doesn't include the voice. It's complicated. Mato is complicated, too.)