> Eg. if you're indiscriminately block all ads whether targetted or not

If the ad industry got together to design the most benign ad technology they can come up with (isolate from host site, no cookies, no js, no video, enforced by iframe security directives) then perhaps adblocking extensions could add an exception for this kind of ad, based on technological criteria, not a manually managed whitelist.

But such a thing does not exist and ads are so intransparent and deeply integrated into pages that one cannot tell, thus blunt hammers need to be applied until no ad is left standing.